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Name | Prostaglandin E2 receptor EP4 subtype |
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Species | Homo sapiens (Human) |
Gene | PTGER4 |
Synonym | Prostanoid EP4 receptor PGE2 receptor EP4 subtype PGE receptor EP4 subtype EP4 receptor EP2 |
Disease | Ulcerative colitis Glaucoma Inflammatory disease Migraine Osteoarthritis [ Show all ] |
Length | 488 |
Amino acid sequence | MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI |
UniProt | P35408 |
Protein Data Bank | 5ywy, 5yhl |
GPCR-HGmod model | P35408 |
3D structure model | This structure is from PDB ID 5ywy. |
BioLiP | BL0434347, BL0434289 |
Therapeutic Target Database | T18876 |
ChEMBL | CHEMBL1836 |
IUPHAR | 343 |
DrugBank | BE0003522 |
Name | CHEMBL3793002 |
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Molecular formula | C21H23F2N3O3 |
IUPAC name | 4-[[6-(4,4-difluoropiperidin-1-yl)-3-methylpyridine-2-carbonyl]amino]-3,5-dimethylbenzoic acid |
Molecular weight | 403.43 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 2 |
XlogP | 4.3 |
Synonyms | 4-[[6-(4,4-difluoro-1-piperidyl)-3-methyl-pyridine-2-carbonyl]amino]-3,5-dimethyl-benzoic acid BRCZKOAZCVSKRY-UHFFFAOYSA-N SCHEMBL15398740 BDBM50163381 |
Inchi Key | BRCZKOAZCVSKRY-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C21H23F2N3O3/c1-12-4-5-16(26-8-6-21(22,23)7-9-26)24-18(12)19(27)25-17-13(2)10-15(20(28)29)11-14(17)3/h4-5,10-11H,6-9H2,1-3H3,(H,25,27)(H,28,29) |
PubChem CID | 86707361 |
ChEMBL | CHEMBL3793002 |
IUPHAR | N/A |
BindingDB | 50163381 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 1.6 nM | PMID27020304 | BindingDB |
IC50 | 1.61 nM | PMID27020304 | ChEMBL |
IC50 | 1160.0 nM | PMID27020304 | BindingDB,ChEMBL |
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