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GPCR

NameGlucagon receptor
SpeciesHomo sapiens (Human)
GeneGCGR
SynonymGL-R
GGR
GR
glucagon receptor
DiseaseDiabetes
Type 2 diabetes
Non-insulin dependent diabetes
Obesity; Diabetes
Type 1 diabetes
[ Show all ]
Length477
Amino acid sequenceMPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProtP47871
Protein Data Bank5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod modelP47871
3D structure modelThis structure is from PDB ID 5yqz.
BioLiPBL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target DatabaseT60182, T87875
ChEMBLCHEMBL1985
IUPHAR251
DrugBankN/A

Ligand

NameCHEMBL3799499
Molecular formulaC29H25Cl2N3O3
IUPAC name3-[[1-[3-(3,5-dichlorophenyl)-5-(2-methylphenyl)pyrazol-1-yl]-2,3-dihydro-1H-indene-5-carbonyl]amino]propanoic acid
Molecular weight534.437
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP6.0
SynonymsBDBM50168098
Inchi KeyCCCCVLGHFKSGSZ-UHFFFAOYSA-N
Inchi IDInChI=1S/C29H25Cl2N3O3/c1-17-4-2-3-5-23(17)27-16-25(20-13-21(30)15-22(31)14-20)33-34(27)26-9-7-18-12-19(6-8-24(18)26)29(37)32-11-10-28(35)36/h2-6,8,12-16,26H,7,9-11H2,1H3,(H,32,37)(H,35,36)
PubChem CID127047122
ChEMBLCHEMBL3799499
IUPHARN/A
BindingDB50168098
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC506900.0 nMPMID27161876BindingDB,ChEMBL
IC5014500.0 nMPMID27161876BindingDB,ChEMBL

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