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GPCR

Name5-hydroxytryptamine receptor 2C
SpeciesRattus norvegicus (Rat)
GeneHtr2c
Synonym5-HT-1C
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
5-HT2C receptor
5-HT-2C
serotonin 1c receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length460
Amino acid sequenceMVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHTNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
UniProtP08909
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL324
IUPHAR8
DrugBankBE0004882

Ligand

NameCHEMBL3819082
Molecular formulaC20H23ClFN
IUPAC name2-[2-(5-fluoro-2,3-dihydro-1H-inden-2-yl)ethyl]-3,4-dihydro-1H-isoquinoline;hydrochloride
Molecular weight331.859
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogPNone
SynonymsSCHEMBL20359741
BDBM50182751
Inchi KeyCPKFIRXOQTXZFK-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H22FN.ClH/c21-20-6-5-17-11-15(12-19(17)13-20)7-9-22-10-8-16-3-1-2-4-18(16)14-22;/h1-6,13,15H,7-12,14H2;1H
PubChem CID127052468
ChEMBLCHEMBL3819082
IUPHARN/A
BindingDB50182751
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessPartition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition>50.0 %PMID27312422ChEMBL

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