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GPCR

NameProbable G-protein coupled receptor 88
SpeciesHomo sapiens (Human)
GeneGPR88
SynonymGPR88
STRG
striatum-specific G-protein coupled receptor
DiseaseN/A
Length384
Amino acid sequenceMTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW
UniProtQ9GZN0
Protein Data BankN/A
GPCR-HGmod modelQ9GZN0
3D structure modelThis predicted structure model is from GPCR-EXP Q9GZN0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3399910
IUPHAR123
DrugBankN/A

Ligand

NameCHEMBL3714828
Molecular formulaC34H38F7N3O6
IUPAC name(1R,2R)-N-[(2S,3S)-2-amino-3-methylpentyl]-2-(6-fluoropyridin-2-yl)-N-[4-(4-propan-2-yloxyphenyl)phenyl]cyclopropane-1-carboxamide;2,2,2-trifluoroacetic acid
Molecular weight717.682
Hydrogen bond acceptor15
Hydrogen bond donor3
XlogPNone
SynonymsN/A
Inchi KeyCQULQAQTUVXMAF-XRYZZEERSA-N
Inchi IDInChI=1S/C30H36FN3O2.2C2HF3O2/c1-5-20(4)27(32)18-34(30(35)26-17-25(26)28-7-6-8-29(31)33-28)23-13-9-21(10-14-23)22-11-15-24(16-12-22)36-19(2)3;2*3-2(4,5)1(6)7/h6-16,19-20,25-27H,5,17-18,32H2,1-4H3;2*(H,6,7)/t20-,25+,26+,27+;;/m0../s1
PubChem CID127024259
ChEMBLCHEMBL3714828
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
EC508.0 nMNoneChEMBL

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