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GPCR

NameGrowth hormone secretagogue receptor type 1
SpeciesHomo sapiens (Human)
GeneGHSR
Synonymghrelin receptor 1a
ghrelin receptor
GH-releasing peptide receptor
GHS-R
growth hormone-releasing peptide receptor
[ Show all ]
DiseaseN/A
Length366
Amino acid sequenceMWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProtQ92847
Protein Data BankN/A
GPCR-HGmod modelQ92847
3D structure modelThis predicted structure model is from GPCR-EXP Q92847.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4616
IUPHAR246
DrugBankBE0003383

Ligand

NameCHEMBL1078533
Molecular formulaC20H28N4O3S
IUPAC name1-[4-[[4-(aminomethyl)phenyl]sulfamoyl]phenyl]-3-hexylurea
Molecular weight404.529
Hydrogen bond acceptor5
Hydrogen bond donor4
XlogP2.6
SynonymsBDBM50311097
N-(4-(aminomethyl)phenyl)-4-(3-hexylureido)benzenesulfonamide
Inchi KeyAGUXGNJNKDLAHB-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H28N4O3S/c1-2-3-4-5-14-22-20(25)23-17-10-12-19(13-11-17)28(26,27)24-18-8-6-16(15-21)7-9-18/h6-13,24H,2-5,14-15,21H2,1H3,(H2,22,23,25)
PubChem CID46882807
ChEMBLCHEMBL1078533
IUPHARN/A
BindingDB50311097
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity5.0 %PMID19767208ChEMBL
IC501715.0 nMPMID19767208BindingDB,ChEMBL

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