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GPCR

NameFree fatty acid receptor 1
SpeciesHomo sapiens (Human)
GeneFFAR1
SynonymFFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
FFA1 receptor
DiseaseType 2 diabetes
Non-insulin dependent diabetes
Diabetes
Length300
Amino acid sequenceMDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProtO14842
Protein Data Bank5tzy, 5tzr
GPCR-HGmod modelO14842
3D structure modelThis structure is from PDB ID 5tzy.
BioLiPBL0380462, BL0380463, BL0380464
Therapeutic Target DatabaseT25608
ChEMBLCHEMBL4422
IUPHAR225
DrugBankBE0000688

Ligand

NameCHEMBL3787110
Molecular formulaC16H18O2
IUPAC name3-[4-(2-cyclopentylethynyl)phenyl]propanoic acid
Molecular weight242.318
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP4.1
SynonymsBDBM50157600
Inchi KeyDAGZZCKKEKNMKE-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H18O2/c17-16(18)12-11-15-9-7-14(8-10-15)6-5-13-3-1-2-4-13/h7-10,13H,1-4,11-12H2,(H,17,18)
PubChem CID127030344
ChEMBLCHEMBL3787110
IUPHARN/A
BindingDB50157600
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50489.78 nMPMID26928019ChEMBL
EC50490.0 nMPMID26928019BindingDB
Efficacy94.0 %PMID26928019ChEMBL

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