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GPCR

NameG-protein coupled receptor 6
SpeciesHomo sapiens (Human)
GeneGPR6
SynonymGPR6
Sphingosine 1-phosphate receptor GPR6
DiseaseN/A
Length362
Amino acid sequenceMNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV
UniProtP46095
Protein Data BankN/A
GPCR-HGmod modelP46095
3D structure modelThis predicted structure model is from GPCR-EXP P46095.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3714130
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3715787
Molecular formulaC22H21ClF4N6O3
IUPAC name3-[4-(4-chloro-2-fluorophenoxy)piperidin-1-yl]-N-cyclopropylpyrazino[2,3-d]pyridazin-2-amine;2,2,2-trifluoroacetic acid
Molecular weight528.893
Hydrogen bond acceptor13
Hydrogen bond donor2
XlogPNone
SynonymsSCHEMBL15566522
Inchi KeyDRBOPWLAOXWXTA-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H20ClFN6O.C2HF3O2/c21-12-1-4-18(15(22)9-12)29-14-5-7-28(8-6-14)20-19(25-13-2-3-13)26-16-10-23-24-11-17(16)27-20;3-2(4,5)1(6)7/h1,4,9-11,13-14H,2-3,5-8H2,(H,25,26);(H,6,7)
PubChem CID90038509
ChEMBLCHEMBL3715787
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
IC5030.0 nMNoneChEMBL

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