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GPCR

NameProbable G-protein coupled receptor 88
SpeciesHomo sapiens (Human)
GeneGPR88
SynonymGPR88
STRG
striatum-specific G-protein coupled receptor
DiseaseN/A
Length384
Amino acid sequenceMTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW
UniProtQ9GZN0
Protein Data BankN/A
GPCR-HGmod modelQ9GZN0
3D structure modelThis predicted structure model is from GPCR-EXP Q9GZN0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3399910
IUPHAR123
DrugBankN/A

Ligand

NameSCHEMBL2520410
Molecular formulaC28H39N3O3
IUPAC name(2S)-N-[(1R)-2-[[(2R)-2-amino-2-cyclopropylacetyl]amino]-1-[4-(2-methylpentoxy)phenyl]ethyl]-2-phenylpropanamide
Molecular weight465.638
Hydrogen bond acceptor4
Hydrogen bond donor3
XlogP4.6
SynonymsCHEMBL3717324
Inchi KeyFCXPXNRKKALRMV-HHNQMVHBSA-N
Inchi IDInChI=1S/C28H39N3O3/c1-4-8-19(2)18-34-24-15-13-22(14-16-24)25(17-30-28(33)26(29)23-11-12-23)31-27(32)20(3)21-9-6-5-7-10-21/h5-7,9-10,13-16,19-20,23,25-26H,4,8,11-12,17-18,29H2,1-3H3,(H,30,33)(H,31,32)/t19?,20-,25-,26+/m0/s1
PubChem CID51355602
ChEMBLCHEMBL3717324
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50100.0 nMNoneChEMBL

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