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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor 6
Species	Homo sapiens (Human)
Gene	GPR6
Synonym	GPR6 Sphingosine 1-phosphate receptor GPR6
Disease	N/A
Length	362
Amino acid sequence	MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV
UniProt	P46095
Protein Data Bank	N/A
GPCR-HGmod model	P46095
3D structure model	This predicted structure model is from GPCR-EXP P46095.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3714130
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL7085534
Molecular formula	C9H9N3O2S2
IUPAC name	N-(2-sulfanylideneimidazolidine-1-carbothioyl)furan-2-carboxamide
Molecular weight	255.31
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	1.0
Synonyms	CHEMBL3715998
Inchi Key	FJDKFXSWBQTFBR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H9N3O2S2/c13-7(6-2-1-5-14-6)11-9(16)12-4-3-10-8(12)15/h1-2,5H,3-4H2,(H,10,15)(H,11,13,16)
PubChem CID	9899809
ChEMBL	CHEMBL3715998
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	68290.0 nM	None	ChEMBL
IC50	160000.0 nM	None	ChEMBL

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