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GPCR

NameProbable G-protein coupled receptor 88
SpeciesHomo sapiens (Human)
GeneGPR88
SynonymGPR88
STRG
striatum-specific G-protein coupled receptor
DiseaseN/A
Length384
Amino acid sequenceMTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW
UniProtQ9GZN0
Protein Data BankN/A
GPCR-HGmod modelQ9GZN0
3D structure modelThis predicted structure model is from GPCR-EXP Q9GZN0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3399910
IUPHAR123
DrugBankN/A

Ligand

NameSCHEMBL2501535
Molecular formulaC23H23NO2S
IUPAC name(1R,2R)-N-[(1R)-2-hydroxy-1-[4-(4-methylphenyl)phenyl]ethyl]-2-thiophen-2-ylcyclopropane-1-carboxamide
Molecular weight377.502
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP3.9
SynonymsCHEMBL3718649
Inchi KeyFTJGKCRCBGQPIG-NJYVYQBISA-N
Inchi IDInChI=1S/C23H23NO2S/c1-15-4-6-16(7-5-15)17-8-10-18(11-9-17)21(14-25)24-23(26)20-13-19(20)22-3-2-12-27-22/h2-12,19-21,25H,13-14H2,1H3,(H,24,26)/t19-,20-,21+/m1/s1
PubChem CID51348370
ChEMBLCHEMBL3718649
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5081.0 nMNoneChEMBL

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