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GPCR

NameProbable G-protein coupled receptor 88
SpeciesHomo sapiens (Human)
GeneGPR88
SynonymGPR88
STRG
striatum-specific G-protein coupled receptor
DiseaseN/A
Length384
Amino acid sequenceMTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW
UniProtQ9GZN0
Protein Data BankN/A
GPCR-HGmod modelQ9GZN0
3D structure modelThis predicted structure model is from GPCR-EXP Q9GZN0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3399910
IUPHAR123
DrugBankN/A

Ligand

NameSCHEMBL2521040
Molecular formulaC25H36N2O2
IUPAC name(2S)-N-[(1R)-1-[4-[(2S)-2-methylbutoxy]phenyl]-2-(propylamino)ethyl]-2-phenylpropanamide
Molecular weight396.575
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP5.4
SynonymsCHEMBL3719078
Inchi KeyFWPPNWSAQZODQM-SKPFHBQLSA-N
Inchi IDInChI=1S/C25H36N2O2/c1-5-16-26-17-24(27-25(28)20(4)21-10-8-7-9-11-21)22-12-14-23(15-13-22)29-18-19(3)6-2/h7-15,19-20,24,26H,5-6,16-18H2,1-4H3,(H,27,28)/t19-,20-,24-/m0/s1
PubChem CID51355599
ChEMBLCHEMBL3719078
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC50100.0 nMNoneChEMBL

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