You can:
Name | Type-1A angiotensin II receptor |
---|---|
Species | Rattus norvegicus (Rat) |
Gene | Agtr1 |
Synonym | Angiotensin II type-1A receptor AT1A |
Disease | N/A for non-human GPCRs |
Length | 359 |
Amino acid sequence | MALNSSAEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYFIENTNITVCAFHYESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCKISDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSDNMSSSAKKPASCFEVE |
UniProt | P25095 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL329 |
IUPHAR | 34 |
DrugBank | N/A |
Name | CHEMBL3787059 |
---|---|
Molecular formula | C23H21ClN4O4 |
IUPAC name | 2-butyl-5-chloro-3-[[4-[2-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid |
Molecular weight | 452.895 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 2 |
XlogP | 5.3 |
Synonyms | BDBM50161275 J3.551.505D 1-[2'-(5-Oxo-4,5-dihydro-1,2,4-oxadiazole-3-yl)-4-biphenylylmethyl]-4-chloro-2-butyl-1H-imidazole-5-carboxylic acid SCHEMBL7018111 |
Inchi Key | GMFYOQSASLSEFN-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C23H21ClN4O4/c1-2-3-8-18-25-20(24)19(22(29)30)28(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21-26-23(31)32-27-21/h4-7,9-12H,2-3,8,13H2,1H3,(H,29,30)(H,26,27,31) |
PubChem CID | 135723840 |
ChEMBL | CHEMBL3787059 |
IUPHAR | N/A |
BindingDB | 50161275 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 2.67 nM | PMID27004954 | ChEMBL |
IC50 | 2.7 nM | PMID27004954 | BindingDB |
Ki | 2.0 nM | PMID27004954 | BindingDB |
Ki | 2.0 nM | PMID27004954 | ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218