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GPCR

NameG-protein coupled receptor 84
SpeciesHomo sapiens (Human)
GeneGPR84
SynonymGPCR4
GPR84
Inflammation-related G-protein coupled receptor EX33
DiseaseN/A
Length396
Amino acid sequenceMWNSSDANFSCYHESVLGYRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVLALVSTWVVGVASFAPLWPIYILVPVVCTCSFDRIRGRPYTTILMGIYFVLGLSSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKVTRMCFAVFLCFALSYIPFLLLNILDARVQAPRVVHMLAANLTWLNGCINPVLYAAMNRQFRQAYGSILKRGPRSFHRLH
UniProtQ9NQS5
Protein Data BankN/A
GPCR-HGmod modelQ9NQS5
3D structure modelThis predicted structure model is from GPCR-EXP Q9NQS5.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3714079
IUPHAR120
DrugBankN/A

Ligand

NameCHEMBL3719125
Molecular formulaC19H21FN2O5
IUPAC name2-[[(2S)-1,4-dioxan-2-yl]methoxy]-9-(2-fluoroethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one
Molecular weight376.384
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP1.4
SynonymsSCHEMBL15051024
Inchi KeyHDGSQKHLTYKQFN-HNNXBMFYSA-N
Inchi IDInChI=1S/C19H21FN2O5/c20-4-6-25-14-1-2-16-13(9-14)3-5-22-17(16)10-18(21-19(22)23)27-12-15-11-24-7-8-26-15/h1-2,9-10,15H,3-8,11-12H2/t15-/m0/s1
PubChem CID89645424
ChEMBLCHEMBL3719125
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50501.0 nMNoneChEMBL

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