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GPCR

NameProbable G-protein coupled receptor 34
SpeciesHomo sapiens (Human)
GeneGPR34
SynonymGPR34
DiseaseN/A
Length381
Amino acid sequenceMRSHTITMTTTSVSSWPYSSHRMRFITNHSDQPPQNFSATPNVTTCPMDEKLLSTVLTTSYSVIFIVGLVGNIIALYVFLGIHRKRNSIQIYLLNVAIADLLLIFCLPFRIMYHINQNKWTLGVILCKVVGTLFYMNMYISIILLGFISLDRYIKINRSIQQRKAITTKQSIYVCCIVWMLALGGFLTMIILTLKKGGHNSTMCFHYRDKHNAKGEAIFNFILVVMFWLIFLLIILSYIKIGKNLLRISKRRSKFPNSGKYATTARNSFIVLIIFTICFVPYHAFRFIYISSQLNVSSCYWKEIVHKTNEIMLVLSSFNSCLDPVMYFLMSSNIRKIMCQLLFRRFQGEPSRSESTSEFKPGYSLHDTSVAVKIQSSSKST
UniProtQ9UPC5
Protein Data BankN/A
GPCR-HGmod modelQ9UPC5
3D structure modelThis predicted structure model is from GPCR-EXP Q9UPC5.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3562165
IUPHAR101
DrugBankN/A

Ligand

NameSCHEMBL3498940
Molecular formulaC29H23ClFNO4S
IUPAC name5-(5-chlorothiophen-2-yl)-2-[[2-[4-[(4-fluorophenyl)methoxy]phenyl]acetyl]amino]-1,3-dihydroindene-2-carboxylic acid
Molecular weight536.014
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP6.4
SynonymsCHEMBL3717898
Inchi KeyIRLJLIKWFVOFKG-UHFFFAOYSA-N
Inchi IDInChI=1S/C29H23ClFNO4S/c30-26-12-11-25(37-26)20-5-6-21-15-29(28(34)35,16-22(21)14-20)32-27(33)13-18-3-9-24(10-4-18)36-17-19-1-7-23(31)8-2-19/h1-12,14H,13,15-17H2,(H,32,33)(H,34,35)
PubChem CID59335736
ChEMBLCHEMBL3717898
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC501000.0 nMNoneChEMBL

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