Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only
Online Services

I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

You can:

GPCR

NameGlucagon-like peptide 2 receptor
SpeciesHomo sapiens (Human)
GeneGLP2R
SynonymGLP-2R
GLP-2-R
GLP-2 receptor
DiseaseDiarrhea
Gastrointestinal disease
Short bowel syndrome
Osteoporosis
Inflammatory bowel disease
Length553
Amino acid sequenceMKLGSSRAGPGRGSAGLLPGVHELPMGIPAPWGTSPLSFHRKCSLWAPGRPFLTLVLLVSIKQVTGSLLEETTRKWAQYKQACLRDLLKEPSGIFCNGTFDQYVCWPHSSPGNVSVPCPSYLPWWSEESSGRAYRHCLAQGTWQTIENATDIWQDDSECSENHSFKQNVDRYALLSTLQLMYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLWPRYLLLGWAFPVLFVVPWGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLKAHQMCFRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGFLVALQYGFANGEVKAELRKYWVRFLLARHSGCRACVLGKDFRFLGKCPKKLSEGDGAEKLRKLQPSLNSGRLLHLAMRGLGELGAQPQQDHARWPRGSSLSECSEGDVTMANTMEEILEESEI
UniProtO95838
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseT34843
ChEMBLCHEMBL5844
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3823976
Molecular formulaC183H284N44O57
IUPAC name(4S)-5-[[1-[[(2R)-1-[[(2S,3R)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-5-amino-1-[[(2S,3R)-1-[[(2S)-6-amino-1-[[(2S,3S)-1-[[(2S,3R)-1-[[(2S)-1-[2-[2-[2-[2-(3-amino-3-oxopropoxy)ethoxy]ethoxy]ethoxy]ethylamino]-3-carboxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-5-oxopentanoic acid
Molecular weight4012.54
Hydrogen bond acceptor61
Hydrogen bond donor54
XlogP-10.5
SynonymsBDBM50183893
Inchi KeyKDJFDVSZWPZDKI-XAWMUJELSA-N
Inchi IDInChI=1S/C183H284N44O57/c1-23-28-50-113(203-159(257)117(55-57-139(238)239)204-168(266)129(82-142(244)245)216-175(273)133(90-229)220-165(263)122(74-105-43-32-29-33-44-105)212-174(272)132(89-228)201-138(237)88-196-156(254)127(80-140(240)241)200-137(236)87-195-154(252)111(185)78-109-86-191-91-197-109)157(255)210-124(76-107-47-36-31-37-48-107)173(271)226-151(104(22)232)182(280)224-147(98(16)26-4)178(276)217-120(72-94(10)11)164(262)215-131(84-144(248)249)169(267)208-119(71-93(8)9)163(261)207-118(70-92(6)7)162(260)199-100(18)152(250)198-101(19)153(251)202-115(53-42-60-193-183(189)190)158(256)214-130(83-143(246)247)170(268)211-123(75-106-45-34-30-35-46-106)172(270)223-146(97(15)25-3)177(275)218-126(79-136(188)235)167(265)213-125(77-108-85-194-112-51-39-38-49-110(108)112)166(264)209-121(73-95(12)13)171(269)222-145(96(14)24-2)176(274)206-116(54-56-134(186)233)161(259)225-149(102(20)230)180(278)205-114(52-40-41-59-184)160(258)221-148(99(17)27-5)179(277)227-150(103(21)231)181(279)219-128(81-141(242)243)155(253)192-61-63-282-65-67-284-69-68-283-66-64-281-62-58-135(187)234/h29-39,43-49,51,85-86,91-104,111,113-133,145-151,194,228-232H,23-28,40-42,50,52-84,87-90,184-185H2,1-22H3,(H2,186,233)(H2,187,234)(H2,188,235)(H,191,197)(H,192,253)(H,195,252)(H,196,254)(H,198,250)(H,199,260)(H,200,236)(H,201,237)(H,202,251)(H,203,257)(H,204,266)(H,205,278)(H,206,274)(H,207,261)(H,208,267)(H,209,264)(H,210,255)(H,211,268)(H,212,272)(H,213,265)(H,214,256)(H,215,262)(H,216,273)(H,217,276)(H,218,275)(H,219,279)(H,220,263)(H,221,258)(H,222,269)(H,223,270)(H,224,280)(H,225,259)(H,226,271)(H,227,277)(H,238,239)(H,240,241)(H,242,243)(H,244,245)(H,246,247)(H,248,249)(H4,189,190,193)/t96-,97-,98-,99-,100-,101-,102+,103+,104+,111-,113?,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124+,125-,126-,127-,128-,129-,130-,131-,132-,133-,145-,146-,147-,148-,149-,150-,151-/m0/s1
PubChem CID127052645
ChEMBLCHEMBL3823976
IUPHARN/A
BindingDB50183893
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC500.03 nMPMID26986178ChEMBL
EC500.03 nMPMID26986178BindingDB

zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218