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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(2) dopamine receptor
Species	Mus musculus (Mouse)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKPDRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61168
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3427
IUPHAR	215
DrugBank	N/A

Ligand

Name	CHEMBL267549
Molecular formula	C25H28ClFN4O
IUPAC name	1-[3-[4-[5-chloro-1-(4-fluorophenyl)indol-3-yl]piperidin-1-yl]propyl]imidazolidin-2-one
Molecular weight	454.974
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	4.4
Synonyms	1-(3-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-propyl)-imidazolidin-2-one BDBM50002004 SCHEMBL8636687 5-Chloro-1-(4-fluorophenyl)-3-[1-[3-(2-oxo-1-imidazolidinyl)propyl]-4-piperidinyl]-1H-indole
Inchi Key	CXAQDXCWRCDSDO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H28ClFN4O/c26-19-2-7-24-22(16-19)23(17-31(24)21-5-3-20(27)4-6-21)18-8-13-29(14-9-18)11-1-12-30-15-10-28-25(30)32/h2-7,16-18H,1,8-15H2,(H,28,32)
PubChem CID	15006460
ChEMBL	CHEMBL267549
IUPHAR	N/A
BindingDB	50002004
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
ED50	57.0 umol.kg-1	PMID1348090	ChEMBL

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