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GPCR

NameProbable G-protein coupled receptor 88
SpeciesHomo sapiens (Human)
GeneGPR88
SynonymGPR88
STRG
striatum-specific G-protein coupled receptor
DiseaseN/A
Length384
Amino acid sequenceMTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW
UniProtQ9GZN0
Protein Data BankN/A
GPCR-HGmod modelQ9GZN0
3D structure modelThis predicted structure model is from GPCR-EXP Q9GZN0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3399910
IUPHAR123
DrugBankN/A

Ligand

NameSCHEMBL2522368
Molecular formulaC29H43N3O3
IUPAC name(2R,3S)-2-amino-3-methyl-N-[(2R)-2-[4-(2-methylpentoxy)phenyl]-2-[[(2S)-2-phenylpropanoyl]amino]ethyl]pentanamide
Molecular weight481.681
Hydrogen bond acceptor4
Hydrogen bond donor3
XlogP5.6
SynonymsCHEMBL3717750
Inchi KeyKQUKOBIYBROAEB-LDEXFZRKSA-N
Inchi IDInChI=1S/C29H43N3O3/c1-6-11-20(3)19-35-25-16-14-24(15-17-25)26(18-31-29(34)27(30)21(4)7-2)32-28(33)22(5)23-12-9-8-10-13-23/h8-10,12-17,20-22,26-27H,6-7,11,18-19,30H2,1-5H3,(H,31,34)(H,32,33)/t20?,21-,22-,26-,27+/m0/s1
PubChem CID51355881
ChEMBLCHEMBL3717750
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC50100.0 nMNoneChEMBL

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