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Name | Muscarinic acetylcholine receptor M3 |
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Species | Homo sapiens (Human) |
Gene | CHRM3 |
Synonym | cholinergic receptor cholinergic receptor, muscarinic 3 cholinergic receptor, muscarinic 3, cardiac Chrm-3 HM4 [ Show all ] |
Disease | Urinary incontinence Overactive bladder Overactive bladder disorder Postoperative nausea and vomiting Respiratory disease [ Show all ] |
Length | 590 |
Amino acid sequence | MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL |
UniProt | P20309 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | T67684 |
ChEMBL | CHEMBL245 |
IUPHAR | 15 |
DrugBank | BE0000045 |
Name | McN-A-343 |
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Molecular formula | C14H18Cl2N2O2 |
IUPAC name | 4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium;chloride |
Molecular weight | 317.21 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | None |
Synonyms | A 343 C 7041 EU-0100277 MCN A-343 chloride SCHEMBL2977744 [ Show all ] |
Inchi Key | CXFZFEJJLNLOTA-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C14H17ClN2O2.ClH/c1-17(2,3)9-4-5-10-19-14(18)16-13-8-6-7-12(15)11-13;/h6-8,11H,9-10H2,1-3H3;1H |
PubChem CID | 5926 |
ChEMBL | CHEMBL74300 |
IUPHAR | 290 |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | Partition coefficient log P of this ligand is not available. |
Parameter | Value | Reference | Database source |
---|---|---|---|
CCh | 3.0 % | Bioorg. Med. Chem. Lett., (1992) 2:8:821 | ChEMBL |
Increase | 7.0 % | Bioorg. Med. Chem. Lett., (1992) 2:8:839 | ChEMBL |
Increase | 13.0 % | Bioorg. Med. Chem. Lett., (1992) 2:8:839 | ChEMBL |
Ki | 2398.83 nM | PMID19896386, PMID24980056 | ChEMBL |
Ki | 5011.87 - 10000.0 nM | PMID7620715 | IUPHAR |
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