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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Rattus norvegicus (Rat)
Gene	Htr6
Synonym	5-HT-6 5-HT6 5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled Serotonin receptor 6 ST-B17 [ Show all ]
Disease	N/A for non-human GPCRs
Length	436
Amino acid sequence	MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTPAPGQCRLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTAGQALETLQVPRTPRPGMESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPPPCGPLTAVPDQASACSRCCLCLCRQTQIQTPLQGAPRACSSQPSFCCLERPPGTPRHPPGPPLWSTSLSQTLWSLRYGRIHSVPP
UniProt	P31388
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3372
IUPHAR	11
DrugBank	N/A

Ligand

Name	CHEMBL3799279
Molecular formula	C26H27ClN6O
IUPAC name	3-[(4-chlorophenyl)-(1-cyclohexyltetrazol-5-yl)methyl]-1,2,5,6-tetrahydroazepino[4,5-b]indol-4-one
Molecular weight	474.993
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.7
Synonyms	3-[alpha-(1-Cyclohexyl-1H-tetrazole-5-yl)-4-chlorobenzyl]-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole-4-one
Inchi Key	MUHWPEYPYZSODI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H27ClN6O/c27-18-12-10-17(11-13-18)25(26-29-30-31-33(26)19-6-2-1-3-7-19)32-15-14-21-20-8-4-5-9-22(20)28-23(21)16-24(32)34/h4-5,8-13,19,25,28H,1-3,6-7,14-16H2
PubChem CID	72696313
ChEMBL	CHEMBL3799279
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	17.0 %	PMID26996373	ChEMBL
log(%)	1.23 -	PMID26996373	ChEMBL

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