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GPCR

NameProlactin-releasing peptide receptor
SpeciesHomo sapiens (Human)
GenePRLHR
SynonymPrRP receptor
hGR3
GPR10
G-protein coupled receptor 10
G protein-coupled receptor 10
[ Show all ]
DiseaseN/A
Length370
Amino acid sequenceMASSTTRGPRVSDLFSGLPPAVTTPANQSAEASAGNGSVAGADAPAVTPFQSLQLVHQLKGLIVLLYSVVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNLALSDVLMCTACVPLTLAYAFEPRGWVFGGGLCHLVFFLQPVTVYVSVFTLTTIAVDRYVVLVHPLRRRISLRLSAYAVLAIWALSAVLALPAAVHTYHVELKPHDVRLCEEFWGSQERQRQLYAWGLLLVTYLLPLLVILLSYVRVSVKLRNRVVPGCVTQSQADWDRARRRRTFCLLVVIVVVFAVCWLPLHVFNLLRDLDPHAIDPYAFGLVQLLCHWLAMSSACYNPFIYAWLHDSFREELRKLLVAWPRKIAPHGQNMTVSVVI
UniProtP49683
Protein Data BankN/A
GPCR-HGmod modelP49683
3D structure modelThis predicted structure model is from GPCR-EXP P49683.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1681611
IUPHAR337
DrugBankN/A

Ligand

NameCHEMBL3731809
Molecular formulaC30H30F3N5O3
IUPAC name4-[3-but-3-ynyl-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-N,N-dimethylbenzamide
Molecular weight565.597
Hydrogen bond acceptor7
Hydrogen bond donor1
XlogP3.1
Synonyms4-{3-(3-butynyl)-4-oxo-2-[(s)-1-(4-trifluoromethylphenyl)ethylamino]-3,5,7,8-tetrahydro-4h-pyrido[4,3-d]pyrimidine-6-carbonyl}-n,n-dimethylbenzamide
BDBM195732
MWJVPVRRNCQMER-IBGZPJMESA-N
US9206173, 2494
Inchi KeyMWJVPVRRNCQMER-IBGZPJMESA-N
Inchi IDInChI=1S/C30H30F3N5O3/c1-5-6-16-38-28(41)24-18-37(27(40)22-9-7-21(8-10-22)26(39)36(3)4)17-15-25(24)35-29(38)34-19(2)20-11-13-23(14-12-20)30(31,32)33/h1,7-14,19H,6,15-18H2,2-4H3,(H,34,35)/t19-/m0/s1
PubChem CID91179414
ChEMBLCHEMBL3731809
IUPHARN/A
BindingDB195732
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Ki201.0 nM, NoneBindingDB,ChEMBL

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