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GPCR

NameC-C chemokine receptor type 10
SpeciesHomo sapiens (Human)
GeneCCR10
SynonymCCR-10
CCR10
CC-CKR-10
G-protein coupled receptor 2
GPR-2
[ Show all ]
DiseaseInflammatory disease
Length362
Amino acid sequenceMGTEATEQVSWGHYSGDEEDAYSAEPLPELCYKADVQAFSRAFQPSVSLTVAALGLAGNGLVLATHLAARRAARSPTSAHLLQLALADLLLALTLPFAAAGALQGWSLGSATCRTISGLYSASFHAGFLFLACISADRYVAIARALPAGPRPSTPGRAHLVSVIVWLLSLLLALPALLFSQDGQREGQRRCRLIFPEGLTQTVKGASAVAQVALGFALPLGVMVACYALLGRTLLAARGPERRRALRVVVALVAAFVVLQLPYSLALLLDTADLLAARERSCPASKRKDVALLVTSGLALARCGLNPVLYAFLGLRFRQDLRRLLRGGSCPSGPQPRRGCPRRPRLSSCSAPTETHSLSWDN
UniProtP46092
Protein Data BankN/A
GPCR-HGmod modelP46092
3D structure modelThis predicted structure model is from GPCR-EXP P46092.
BioLiPN/A
Therapeutic Target DatabaseT71054
ChEMBLCHEMBL2321628
IUPHAR67
DrugBankN/A

Ligand

NameCHEMBL3728115
Molecular formulaC27H28ClN7O4S
IUPAC name1-[7-(2-chloroanilino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidin-3-yl]sulfonyl-3-ethylurea
Molecular weight582.076
Hydrogen bond acceptor7
Hydrogen bond donor3
XlogP4.0
SynonymsSCHEMBL14471827
NWKNUOMUNGHYGU-UHFFFAOYSA-N
7-(2-chlorophenylamino)-N-(ethylcarbamoyl)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine-3-sulfonamide
Inchi KeyNWKNUOMUNGHYGU-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H28ClN7O4S/c1-2-29-27(37)33-40(38,39)23-17-31-35-24(32-22-11-7-6-10-21(22)28)20(16-30-25(23)35)26(36)34-14-12-19(13-15-34)18-8-4-3-5-9-18/h3-11,16-17,19,32H,2,12-15H2,1H3,(H2,29,33,37)
PubChem CID71178974
ChEMBLCHEMBL3728115
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition92.4 %NoneChEMBL

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