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GPCR

NameNeuromedin-U receptor 2
SpeciesHomo sapiens (Human)
GeneNMUR2
SynonymG-protein coupled receptor FM-4
G-protein coupled receptor TGR-1
FM4
NMU-R2
NMU2 receptor
[ Show all ]
DiseaseN/A
Length415
Amino acid sequenceMSGMEKLQNASWIYQQKLEDPFQKHLNSTEEYLAFLCGPRRSHFFLPVSVVYVPIFVVGVIGNVLVCLVILQHQAMKTPTNYYLFSLAVSDLLVLLLGMPLEVYEMWRNYPFLFGPVGCYFKTALFETVCFASILSITTVSVERYVAILHPFRAKLQSTRRRALRILGIVWGFSVLFSLPNTSIHGIKFHYFPNGSLVPGSATCTVIKPMWIYNFIIQVTSFLFYLLPMTVISVLYYLMALRLKKDKSLEADEGNANIQRPCRKSVNKMLFVLVLVFAICWAPFHIDRLFFSFVEEWSESLAAVFNLVHVVSGVFFYLSSAVNPIIYNLLSRRFQAAFQNVISSFHKQWHSQHDPQLPPAQRNIFLTECHFVELTEDIGPQFPCQSSMHNSHLPAALSSEQMSRTNYQSFHFNKT
UniProtQ9GZQ4
Protein Data BankN/A
GPCR-HGmod modelQ9GZQ4
3D structure modelThis predicted structure model is from GPCR-EXP Q9GZQ4.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1075144
IUPHAR299
DrugBankN/A

Ligand

NameCHEMBL3759505
Molecular formulaC67H110N16O10
IUPAC name(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-1-[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-(hexadecanoylamino)-2-methylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-2-methyl-3-phenylpropanoyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]-methylamino]butanediamide
Molecular weight1299.72
Hydrogen bond acceptor12
Hydrogen bond donor12
XlogP5.9
SynonymsN/A
Inchi KeyOZHGPZIBAKJIOR-VCFWISSKSA-N
Inchi IDInChI=1S/C67H110N16O10/c1-8-9-10-11-12-13-14-15-16-17-18-19-26-37-55(85)80-66(4,5)62(92)79-51(42-46-30-22-20-23-31-46)57(87)77-50(41-45(2)3)58(88)81-67(6,44-47-32-24-21-25-33-47)63(93)78-49(35-28-39-75-65(72)73)61(91)83-40-29-36-52(83)59(89)76-48(34-27-38-74-64(70)71)60(90)82(7)53(56(69)86)43-54(68)84/h20-25,30-33,45,48-53H,8-19,26-29,34-44H2,1-7H3,(H2,68,84)(H2,69,86)(H,76,89)(H,77,87)(H,78,93)(H,79,92)(H,80,85)(H,81,88)(H4,70,71,74)(H4,72,73,75)/t48-,49-,50-,51-,52-,53-,67-/m0/s1
PubChem CID127027016
ChEMBLCHEMBL3759505
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Emax19.2 %PMID26204509ChEMBL

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