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Name | D(2) dopamine receptor |
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Species | Homo sapiens (Human) |
Gene | DRD2 |
Synonym | dopamine receptor 2 Dopamine D2 receptor D2R D2A and D2B D2(415) and D2(444) [ Show all ] |
Disease | Substance dependence Major depressive disorder Maintain blood pressure in hypotensive states Insomnia Inflammatory disease [ Show all ] |
Length | 443 |
Amino acid sequence | MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC |
UniProt | P14416 |
Protein Data Bank | 6cm4, 6c38 |
GPCR-HGmod model | P14416 |
3D structure model | This structure is from PDB ID 6cm4. |
BioLiP | BL0408379, BL0403379 |
Therapeutic Target Database | T67162 |
ChEMBL | CHEMBL217 |
IUPHAR | 215 |
DrugBank | BE0000756 |
Name | CHEMBL3798748 |
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Molecular formula | C28H32N2O6 |
IUPAC name | 5-hydroxy-8-[(1R)-1-hydroxy-2-[2-[3-methoxy-4-(3-phenylpropoxy)phenyl]ethylamino]ethyl]-4H-1,4-benzoxazin-3-one |
Molecular weight | 492.572 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 4 |
XlogP | 3.5 |
Synonyms | BDBM50166979 J3.552.948I 5-Hydroxy-8-[(1R)-1-hydroxy-2-[[2-[3-methoxy-4-(3-phenylpropoxy)phenyl]ethyl]amino]ethyl]-2H-1,4-benzooxazine-3(4H)-one |
Inchi Key | VAGMAHDJGBPZIB-QHCPKHFHSA-N |
Inchi ID | InChI=1S/C28H32N2O6/c1-34-25-16-20(9-12-24(25)35-15-5-8-19-6-3-2-4-7-19)13-14-29-17-23(32)21-10-11-22(31)27-28(21)36-18-26(33)30-27/h2-4,6-7,9-12,16,23,29,31-32H,5,8,13-15,17-18H2,1H3,(H,30,33)/t23-/m0/s1 |
PubChem CID | 127045853 |
ChEMBL | CHEMBL3798748 |
IUPHAR | N/A |
BindingDB | 50166979 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 98.0 nM | PMID27132867 | BindingDB,ChEMBL |
EC50 | 13000.0 nM | PMID27132867 | BindingDB,ChEMBL |
Emax | 85.0 % | PMID27132867 | ChEMBL |
Emax | 92.0 % | PMID27132867 | ChEMBL |
Ki | 65.0 nM | PMID27132867 | BindingDB,ChEMBL |
Ki | 130.0 nM | PMID27132867 | BindingDB,ChEMBL |
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