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GPCR

NameNociceptin receptor
SpeciesHomo sapiens (Human)
GeneOPRL1
SynonymMOR-C
KOR-3
NOP receptor
N/OFQ receptor
nociceptin receptor ORL1
[ Show all ]
DiseasePsychiatric disorder
Pain; Stress
Pain
Major depressive disorder
Inflammatory disease
[ Show all ]
Length370
Amino acid sequenceMEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
UniProtP41146
Protein Data Bank5dhg, 4ea3, 5dhh
GPCR-HGmod modelP41146
3D structure modelThis structure is from PDB ID 5dhg.
BioLiPBL0328039,BL0328040, BL0227293,BL0227294, BL0328041,BL0328042
Therapeutic Target DatabaseT52921
ChEMBLCHEMBL2014
IUPHAR320
DrugBankBE0002378

Ligand

NameSCHEMBL3413519
Molecular formulaC32H38N6O2
IUPAC name2-N-[4-(dimethylamino)-1,4-diphenylcyclohexyl]-6-(4-methoxyphenoxy)-2-N,4-N-dimethyl-1,3,5-triazine-2,4-diamine
Molecular weight538.696
Hydrogen bond acceptor8
Hydrogen bond donor1
XlogP6.5
SynonymsCHEMBL3896402
BDBM239917
US9403767, 91
Inchi KeyAHTGEUVXEZBNCV-UHFFFAOYSA-N
Inchi IDInChI=1S/C32H38N6O2/c1-33-28-34-29(36-30(35-28)40-27-18-16-26(39-5)17-19-27)38(4)32(25-14-10-7-11-15-25)22-20-31(21-23-32,37(2)3)24-12-8-6-9-13-24/h6-19H,20-23H2,1-5H3,(H,33,34,35,36)
PubChem CID44253138
ChEMBLCHEMBL3896402
IUPHARN/A
BindingDB239917
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki5.35 nM, NoneBindingDB,ChEMBL

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