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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanocortin receptor 5
Species	Homo sapiens (Human)
Gene	MC5R
Synonym	melanocortin receptor 5 MC5R MC5-R MC5 receptor MC-2
Disease	Acne vulgaris Seborrhea
Length	325
Amino acid sequence	MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD
UniProt	P33032
Protein Data Bank	N/A
GPCR-HGmod model	P33032
3D structure model	This predicted structure model is from GPCR-EXP P33032.
BioLiP	N/A
Therapeutic Target Database	T95302
ChEMBL	CHEMBL4608
IUPHAR	286
DrugBank	N/A

Ligand

Name	SCHEMBL2347332
Molecular formula	C34H42N6O2
IUPAC name	N-[[(3S,5S)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-2,3-dihydro-1H-indene-2-carboxamide
Molecular weight	566.75
Hydrogen bond acceptor	4
Hydrogen bond donor	4
XlogP	3.4
Synonyms	US9340517, 133 CHEMBL3896317 BDBM231747
Inchi Key	BHYXUUNNKRKTBD-SMCANUKXSA-N
Inchi ID	InChI=1S/C34H42N6O2/c35-34(36)37-18-9-16-31-33(42)40(23-30(24-10-3-1-4-11-24)25-12-5-2-6-13-25)19-17-29(39-31)22-38-32(41)28-20-26-14-7-8-15-27(26)21-28/h1-8,10-15,28-31,39H,9,16-23H2,(H,38,41)(H4,35,36,37)/t29-,31-/m0/s1
PubChem CID	44206024
ChEMBL	CHEMBL3896317
IUPHAR	N/A
BindingDB	231747
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	>10000.0 nM	, None	BindingDB,ChEMBL

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