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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Melanocortin receptor 5
Species	Homo sapiens (Human)
Gene	MC5R
Synonym	melanocortin receptor 5 MC5R MC5-R MC5 receptor MC-2
Disease	Acne vulgaris Seborrhea
Length	325
Amino acid sequence	MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD
UniProt	P33032
Protein Data Bank	N/A
GPCR-HGmod model	P33032
3D structure model	This predicted structure model is from GPCR-EXP P33032.
BioLiP	N/A
Therapeutic Target Database	T95302
ChEMBL	CHEMBL4608
IUPHAR	286
DrugBank	N/A

Ligand

Name	SCHEMBL2349052
Molecular formula	C29H32Cl2N4O2
IUPAC name	N-[[(3S,5S)-3-(2-aminoethyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3,4-dichlorobenzamide
Molecular weight	539.501
Hydrogen bond acceptor	4
Hydrogen bond donor	3
XlogP	4.6
Synonyms	US9340517, 280 CHEMBL3900891 BDBM231893
Inchi Key	BWKKOIFSAZINTN-HOFKKMOUSA-N
Inchi ID	InChI=1S/C29H32Cl2N4O2/c30-25-12-11-22(17-26(25)31)28(36)33-18-23-14-16-35(29(37)27(34-23)13-15-32)19-24(20-7-3-1-4-8-20)21-9-5-2-6-10-21/h1-12,17,23-24,27,34H,13-16,18-19,32H2,(H,33,36)/t23-,27-/m0/s1
PubChem CID	46896762
ChEMBL	CHEMBL3900891
IUPHAR	N/A
BindingDB	231893
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	>1000.0 nM	, None	BindingDB,ChEMBL

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