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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Cannabinoid receptor 1
Species	Mus musculus (Mouse)
Gene	Cnr1
Synonym	SKR6R Neuronal cannabinoid receptor Central cannabinoid receptor CB1R CB1 receptor CB1 CB-R Cann7 Cann6 Brain-type cannabinoid receptor THC receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	473
Amino acid sequence	MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEDNIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
UniProt	P47746
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3037
IUPHAR	56
DrugBank	N/A

Ligand

Name	JWH 073 N-(4-hydroxybutyl) metabolite
Molecular formula	C23H21NO2
IUPAC name	[1-(4-hydroxybutyl)indol-3-yl]-naphthalen-1-ylmethanone
Molecular weight	343.426
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.6
Synonyms	1058AH JWH-073 4-Hydroxybutyl metabolite solution, 100 mug/mL in methanol, ampule of 1 mL, certified reference material BDBM60993 ZINC64858596 (1-(4-Hydroxybutyl)-1H-indol-3-yl)(naphthalen-1-yl)methanone FIBVDFAPDNJBNI-UHFFFAOYSA-N 335161-14-3 SCHEMBL15112081 1-(4-Hydroxybutyl)-3-(1-naphthylcarbonyl)-1H-indole US9416103, JWH-073-M5 CHEMBL3916546 [ Show all ]
Inchi Key	FIBVDFAPDNJBNI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H21NO2/c25-15-6-5-14-24-16-21(19-11-3-4-13-22(19)24)23(26)20-12-7-9-17-8-1-2-10-18(17)20/h1-4,7-13,16,25H,5-6,14-15H2
PubChem CID	53394456
ChEMBL	CHEMBL3916546
IUPHAR	N/A
BindingDB	60993
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	224.2 nM	, None	BindingDB,ChEMBL

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