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GPCR

NameParathyroid hormone/parathyroid hormone-related peptide receptor
SpeciesRattus norvegicus (Rat)
GenePth1r
SynonymParathyroid hormone 1 receptor
PPR
PTH/PTHr receptor
PTH/PTHrP type I receptor
PTH1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length591
Amino acid sequenceMGAARIAPSLALLLCCPVLSSAYALVDADDVFTKEEQIFLLHRAQAQCDKLLKEVLHTAANIMESDKGWTPASTSGKPRKEKASGKFYPESKENKDVPTGSRRRGRPCLPEWDNIVCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWEVVPGHNRTWANYSECLKFMTNETREREVFDRLGMIYTVGYSMSLASLTVAVLILAYFRRLHCTRNYIHMHMFLSFMLRAASIFVKDAVLYSGFTLDEAERLTEEELHIIAQVPPPPAAAAVGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTIFGWGLPAVFVAVWVGVRATLANTGCWDLSSGHKKWIIQVPILASVVLNFILFINIIRVLATKLRETNAGRCDTRQQYRKLLRSTLVLVPLFGVHYTVFMALPYTEVSGTLWQIQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIRKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRAGLSLPLSPRLPPATTNGHSQLPGHAKPGAPATETETLPVTMAVPKDDGFLNGSCSGLDEEASGSARPPPLLQEEWETVM
UniProtP25961
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL6038
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3962850
Molecular formulaC31H34F3N5O6S
IUPAC name1-[3,5-dimethyl-4-[2-[[4-oxo-2-[4-(trifluoromethoxy)phenyl]-1,3,8-triazaspiro[4.5]dec-1-en-8-yl]sulfonyl]ethyl]phenyl]-1,3-diazaspiro[4.4]nonane-2,4-dione
Molecular weight661.697
Hydrogen bond acceptor11
Hydrogen bond donor2
XlogP4.2
SynonymsUS9428505, Compound 8
BDBM64564
SCHEMBL17104841
Inchi KeyXRQFZVXCVAFCOM-UHFFFAOYSA-N
Inchi IDInChI=1S/C31H34F3N5O6S/c1-19-17-22(39-28(42)36-27(41)30(39)10-3-4-11-30)18-20(2)24(19)9-16-46(43,44)38-14-12-29(13-15-38)26(40)35-25(37-29)21-5-7-23(8-6-21)45-31(32,33)34/h5-8,17-18H,3-4,9-16H2,1-2H3,(H,35,37,40)(H,36,41,42)
PubChem CID76283959
ChEMBLCHEMBL3962850
IUPHARN/A
BindingDB64564
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC501900.0 nM, NoneBindingDB,ChEMBL

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