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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H2 receptor
Species	Cavia porcellus (Guinea pig)
Gene	HRH2
Synonym	Gastric receptor I H2R HH2R
Disease	N/A for non-human GPCRs
Length	359
Amino acid sequence	MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSLAVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNEVYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVMGAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYHQLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
UniProt	P47747
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2882
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL308685
Molecular formula	C26H36N6O3S
IUPAC name	1-[2-(benzenesulfonamido)ethyl]-3-cyano-2-[4-[3-(piperidin-1-ylmethyl)phenoxy]butyl]guanidine
Molecular weight	512.673
Hydrogen bond acceptor	7
Hydrogen bond donor	3
XlogP	3.3
Synonyms	1-[2-(Phenylsulfonylamino)ethyl]-2-cyano-3-[4-[3-(1-piperidinylmethyl)phenoxy]butyl]guanidine
Inchi Key	AEEXSDDDKFLWGP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H36N6O3S/c27-22-30-26(29-15-16-31-36(33,34)25-12-3-1-4-13-25)28-14-5-8-19-35-24-11-9-10-23(20-24)21-32-17-6-2-7-18-32/h1,3-4,9-13,20,31H,2,5-8,14-19,21H2,(H2,28,29,30)
PubChem CID	15179539
ChEMBL	CHEMBL308685
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
pKB	7.28 -	PMID1613748	ChEMBL

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