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Name | Glucagon-like peptide 1 receptor |
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Species | Homo sapiens (Human) |
Gene | GLP1R |
Synonym | glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor |
Disease | Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis [ Show all ] |
Length | 463 |
Amino acid sequence | MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS |
UniProt | P43220 |
Protein Data Bank | 5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv |
GPCR-HGmod model | P43220 |
3D structure model | This structure is from PDB ID 5vex. |
BioLiP | BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966 |
Therapeutic Target Database | T36075 |
ChEMBL | CHEMBL1784 |
IUPHAR | 249 |
DrugBank | BE0000857 |
Name | SCHEMBL2017314 |
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Molecular formula | C48H43Cl2N3O7 |
IUPAC name | (2S)-2-[[(3S,8S)-3-[4-[(3,4-dichlorophenyl)methoxy]phenyl]-7-[(1S)-1-phenylpropyl]-3,6,8,9-tetrahydro-2H-[1,4]dioxino[2,3-g]isoquinoline-8-carbonyl]amino]-3-(4-pyridin-4-yloxyphenyl)propanoic acid |
Molecular weight | 844.786 |
Hydrogen bond acceptor | 9 |
Hydrogen bond donor | 2 |
XlogP | 7.3 |
Synonyms | US9175003, 184 CHEMBL3973195 BDBM190024 |
Inchi Key | AFWCGPRDQKWXQQ-WWKIHPBISA-N |
Inchi ID | InChI=1S/C48H43Cl2N3O7/c1-2-42(32-6-4-3-5-7-32)53-27-35-26-45-44(58-29-46(60-45)33-11-15-36(16-12-33)57-28-31-10-17-39(49)40(50)22-31)25-34(35)24-43(53)47(54)52-41(48(55)56)23-30-8-13-37(14-9-30)59-38-18-20-51-21-19-38/h3-22,25-26,41-43,46H,2,23-24,27-29H2,1H3,(H,52,54)(H,55,56)/t41-,42-,43-,46+/m0/s1 |
PubChem CID | 49804426 |
ChEMBL | CHEMBL3973195 |
IUPHAR | N/A |
BindingDB | 190024 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
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EC50 | 74.0 nM | , None | BindingDB,ChEMBL |
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