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GPCR

NameOrexin receptor type 2
SpeciesHomo sapiens (Human)
GeneHCRTR2
SynonymOx-2-R
OX2 receptor
Ox2-R
OX2R
orexin receptor type 2
[ Show all ]
DiseaseInsomnia
Length444
Amino acid sequenceMSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
UniProtO43614
Protein Data Bank5ws3, 5wqc, 4s0v, 4rnb
GPCR-HGmod modelO43614
3D structure modelThis structure is from PDB ID 5ws3.
BioLiPBL0303710, BL0398950, BL0397818, BL0302679
Therapeutic Target DatabaseT69485
ChEMBLCHEMBL4792
IUPHAR322
DrugBankBE0005865

Ligand

NameSCHEMBL16465942
Molecular formulaC23H21ClN6O3
IUPAC name[5-chloro-2-(triazol-2-yl)phenyl]-[(2S)-2-[5-(2-methoxy-5-methylphenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]methanone
Molecular weight464.91
Hydrogen bond acceptor7
Hydrogen bond donor0
XlogP4.3
SynonymsUS9493446, 417
BDBM257948
Inchi KeyAIKROLIVVRRROF-IBGZPJMESA-N
Inchi IDInChI=1S/C23H21ClN6O3/c1-14-5-8-20(32-2)17(12-14)22-27-21(28-33-22)19-4-3-11-29(19)23(31)16-13-15(24)6-7-18(16)30-25-9-10-26-30/h5-10,12-13,19H,3-4,11H2,1-2H3/t19-/m0/s1
PubChem CID117872784
ChEMBLN/A
IUPHARN/A
BindingDB257948
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5021.0 nMN/ABindingDB

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