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GPCR

NameC-C chemokine receptor type 10
SpeciesMus musculus (Mouse)
GeneCcr10
SynonymCC-CKR-10
GPR-2
G-protein coupled receptor 2
CCR10
Chemokine C-C receptor 9
[ Show all ]
DiseaseN/A for non-human GPCRs
Length362
Amino acid sequenceMGTKPTEQVSWGLYSGYDEEAYSVGPLPELCYKADVQAFSRAFQPSVSLMVAVLGLAGNGLVLATHLAARRTTRSPTSVHLLQLALADLLLALTLPFAAAGALQGWNLGSTTCRAISGLYSASFHAGFLFLACISADRYVAIARALPAGQRPSTPSRAHLVSVFVWLLSLFLALPALLFSRDGPREGQRRCRLIFPESLTQTVKGASAVAQVVLGFALPLGVMAACYALLGRTLLAARGPERRRALRVVVALVVAFVVLQLPYSLALLLDTADLLAARERSCSSSKRKDLALLVTGGLTLVRCSLNPVLYAFLGLRFRRDLRRLLQGGGCSPKPNPRGRCPRRLRLSSCSAPTETHSLSWDN
UniProtQ9JL21
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3879821
IUPHAR67
DrugBankN/A

Ligand

NameCHEMBL3919363
Molecular formulaC20H24Cl2N6O3S
IUPAC name4-amino-3,5-dichloro-N-[4-(5-cyanopyrazol-1-yl)-1-(4-methylpiperidin-1-yl)-1-oxobutan-2-yl]benzenesulfonamide
Molecular weight499.411
Hydrogen bond acceptor7
Hydrogen bond donor2
XlogP2.7
SynonymsSCHEMBL1077312
BDBM50198919
Inchi KeyAJOHGFSOOMQDMR-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H24Cl2N6O3S/c1-13-3-7-27(8-4-13)20(29)18(5-9-28-14(12-23)2-6-25-28)26-32(30,31)15-10-16(21)19(24)17(22)11-15/h2,6,10-11,13,18,26H,3-5,7-9,24H2,1H3
PubChem CID58509038
ChEMBLCHEMBL3919363
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC503162.28 nMPMID27692854ChEMBL

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