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GPCR

NameTrace amine-associated receptor 1
SpeciesRattus norvegicus (Rat)
GeneTaar1
SynonymTRAR1
TaR-1
Trace amine receptor 1
TAR1
TA1 receptor
DiseaseN/A for non-human GPCRs
Length332
Amino acid sequenceMHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
UniProtQ923Y9
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3833
IUPHAR364
DrugBankN/A

Ligand

NameCHEMBL3954579
Molecular formulaC19H18FN3O
IUPAC name(2R)-2-[4-[1-(4-fluorophenyl)pyrazol-4-yl]phenyl]morpholine
Molecular weight323.371
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP2.6
SynonymsSCHEMBL15111580
BDBM190620
US9181230, 26
Inchi KeyANIXSCDCEWNQJP-IBGZPJMESA-N
Inchi IDInChI=1S/C19H18FN3O/c20-17-5-7-18(8-6-17)23-13-16(11-22-23)14-1-3-15(4-2-14)19-12-21-9-10-24-19/h1-8,11,13,19,21H,9-10,12H2/t19-/m0/s1
PubChem CID71656802
ChEMBLCHEMBL3954579
IUPHARN/A
BindingDB190620
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki12.2 nM, NoneBindingDB,ChEMBL
Ki66.9 nMNoneChEMBL

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