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GPCR

NameTrace amine-associated receptor 1
SpeciesMus musculus (Mouse)
GeneTaar1
SynonymTRAR1
TA1 receptor
TAR1
trace amine receptor 1
TaR-1
DiseaseN/A for non-human GPCRs
Length332
Amino acid sequenceMHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL
UniProtQ923Y8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4908
IUPHAR364
DrugBankN/A

Ligand

NameSCHEMBL6919602
Molecular formulaC18H19F2N3O
IUPAC name3,5-difluoro-N-[4-(2-pyrrolidin-3-ylethyl)phenyl]pyridine-2-carboxamide
Molecular weight331.367
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP2.8
SynonymsBDBM250223
CHEMBL3907834
US9452980, 133
Inchi KeyAPWHZOSSXYMDSS-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H19F2N3O/c19-14-9-16(20)17(22-11-14)18(24)23-15-5-3-12(4-6-15)1-2-13-7-8-21-10-13/h3-6,9,11,13,21H,1-2,7-8,10H2,(H,23,24)
PubChem CID67241233
ChEMBLCHEMBL3907834
IUPHARN/A
BindingDB250223
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki1522.8 nM, NoneBindingDB,ChEMBL

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