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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL3966709
Molecular formula	C24H32N4O3
IUPAC name	tert-butyl 4-[cyclopropyl-[4-(3-methylimidazol-4-yl)benzoyl]amino]piperidine-1-carboxylate
Molecular weight	424.545
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.1
Synonyms	SCHEMBL15507278 4-{Cyclopropyl-[4-(3-methyl-3H-imidazol-4-yl)-benzoyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester US9469631, 42 BCHGUZHBMYZIGP-UHFFFAOYSA-N BDBM254642
Inchi Key	BCHGUZHBMYZIGP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H32N4O3/c1-24(2,3)31-23(30)27-13-11-20(12-14-27)28(19-9-10-19)22(29)18-7-5-17(6-8-18)21-15-25-16-26(21)4/h5-8,15-16,19-20H,9-14H2,1-4H3
PubChem CID	89995652
ChEMBL	CHEMBL3966709
IUPHAR	N/A
BindingDB	254642
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	152.0 nM	, None	BindingDB,ChEMBL

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