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GPCR

NameTrace amine-associated receptor 1
SpeciesRattus norvegicus (Rat)
GeneTaar1
SynonymTRAR1
TaR-1
Trace amine receptor 1
TAR1
TA1 receptor
DiseaseN/A for non-human GPCRs
Length332
Amino acid sequenceMHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
UniProtQ923Y9
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3833
IUPHAR364
DrugBankN/A

Ligand

NameSCHEMBL6920953
Molecular formulaC17H18N2O3
IUPAC name4-hydroxy-N-(4-morpholin-2-ylphenyl)benzamide
Molecular weight298.342
Hydrogen bond acceptor4
Hydrogen bond donor3
XlogP1.4
SynonymsCHEMBL3919850
BDBM250289
US9452980, 199
Inchi KeyBEDISQHEGSGZGM-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H18N2O3/c20-15-7-3-13(4-8-15)17(21)19-14-5-1-12(2-6-14)16-11-18-9-10-22-16/h1-8,16,18,20H,9-11H2,(H,19,21)
PubChem CID67240970
ChEMBLCHEMBL3919850
IUPHARN/A
BindingDB250289
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki238.1 nM, NoneBindingDB,ChEMBL

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