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GPCR

NameTrace amine-associated receptor 1
SpeciesRattus norvegicus (Rat)
GeneTaar1
SynonymTRAR1
TaR-1
Trace amine receptor 1
TAR1
TA1 receptor
DiseaseN/A for non-human GPCRs
Length332
Amino acid sequenceMHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
UniProtQ923Y9
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3833
IUPHAR364
DrugBankN/A

Ligand

NameSCHEMBL1990549
Molecular formulaC19H21ClN2O2
IUPAC name4-chloro-3-methoxy-N-[4-[(3R)-piperidin-3-yl]phenyl]benzamide
Molecular weight344.839
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP3.5
SynonymsCHEMBL3953805
BDBM250290
ZINC117714810
US9452980, 200
Benzamide, 4-chloro-3-methoxy-N-[4-(3R)-3-piperidinylphenyl]-
[ Show all ]
Inchi KeyBHRQCRFMVOTRQJ-HNNXBMFYSA-N
Inchi IDInChI=1S/C19H21ClN2O2/c1-24-18-11-14(6-9-17(18)20)19(23)22-16-7-4-13(5-8-16)15-3-2-10-21-12-15/h4-9,11,15,21H,2-3,10,12H2,1H3,(H,22,23)/t15-/m0/s1
PubChem CID67239041
ChEMBLCHEMBL3953805
IUPHARN/A
BindingDB250290
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki2.2 nM, NoneBindingDB,ChEMBL

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