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GPCR

NameC-C chemokine receptor type 10
SpeciesMus musculus (Mouse)
GeneCcr10
SynonymCC-CKR-10
GPR-2
G-protein coupled receptor 2
CCR10
Chemokine C-C receptor 9
[ Show all ]
DiseaseN/A for non-human GPCRs
Length362
Amino acid sequenceMGTKPTEQVSWGLYSGYDEEAYSVGPLPELCYKADVQAFSRAFQPSVSLMVAVLGLAGNGLVLATHLAARRTTRSPTSVHLLQLALADLLLALTLPFAAAGALQGWNLGSTTCRAISGLYSASFHAGFLFLACISADRYVAIARALPAGQRPSTPSRAHLVSVFVWLLSLFLALPALLFSRDGPREGQRRCRLIFPESLTQTVKGASAVAQVVLGFALPLGVMAACYALLGRTLLAARGPERRRALRVVVALVVAFVVLQLPYSLALLLDTADLLAARERSCSSSKRKDLALLVTGGLTLVRCSLNPVLYAFLGLRFRRDLRRLLQGGGCSPKPNPRGRCPRRLRLSSCSAPTETHSLSWDN
UniProtQ9JL21
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3879821
IUPHAR67
DrugBankN/A

Ligand

NameCHEMBL3889627
Molecular formulaC23H27N5O3S
IUPAC nameN-[4-(2-cyanopyrrol-1-yl)-1-(4-methylpiperidin-1-yl)-1-oxobutan-2-yl]-1H-indole-4-sulfonamide
Molecular weight453.561
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP2.6
SynonymsSCHEMBL1034287
BDBM50198921
Inchi KeyBRJXJOWXAFLRTE-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H27N5O3S/c1-17-8-13-28(14-9-17)23(29)21(10-15-27-12-3-4-18(27)16-24)26-32(30,31)22-6-2-5-20-19(22)7-11-25-20/h2-7,11-12,17,21,25-26H,8-10,13-15H2,1H3
PubChem CID44252324
ChEMBLCHEMBL3889627
IUPHARN/A
BindingDB50198921
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5025.12 nMPMID27692854ChEMBL
IC5063.1 nMPMID27692854ChEMBL
IC5015848.9 nMPMID27692854ChEMBL

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