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GPCR

NameTrace amine-associated receptor 1
SpeciesMus musculus (Mouse)
GeneTaar1
SynonymTRAR1
TA1 receptor
TAR1
trace amine receptor 1
TaR-1
DiseaseN/A for non-human GPCRs
Length332
Amino acid sequenceMHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL
UniProtQ923Y8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4908
IUPHAR364
DrugBankN/A

Ligand

NameSCHEMBL6919539
Molecular formulaC26H26N2O5
IUPAC namemethyl 4-[[4-[(4-morpholin-2-ylphenyl)carbamoyl]phenoxy]methyl]benzoate
Molecular weight446.503
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP3.1
SynonymsBDBM250301
CHEMBL3919815
US9452980, 211
Inchi KeyBWCYBKOHQWMMEA-UHFFFAOYSA-N
Inchi IDInChI=1S/C26H26N2O5/c1-31-26(30)21-4-2-18(3-5-21)17-33-23-12-8-20(9-13-23)25(29)28-22-10-6-19(7-11-22)24-16-27-14-15-32-24/h2-13,24,27H,14-17H2,1H3,(H,28,29)
PubChem CID67240705
ChEMBLCHEMBL3919815
IUPHARN/A
BindingDB250301
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki4.0 nM, NoneBindingDB,ChEMBL

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