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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Trace amine-associated receptor 1
Species	Rattus norvegicus (Rat)
Gene	Taar1
Synonym	TA1 receptor TaR-1 TAR1 Trace amine receptor 1 TRAR1
Disease	N/A for non-human GPCRs
Length	332
Amino acid sequence	MHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
UniProt	Q923Y9
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3833
IUPHAR	364
DrugBank	N/A

Ligand

Name	SCHEMBL6919539
Molecular formula	C26H26N2O5
IUPAC name	methyl 4-[[4-[(4-morpholin-2-ylphenyl)carbamoyl]phenoxy]methyl]benzoate
Molecular weight	446.503
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	3.1
Synonyms	US9452980, 211 CHEMBL3919815 BDBM250301
Inchi Key	BWCYBKOHQWMMEA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H26N2O5/c1-31-26(30)21-4-2-18(3-5-21)17-33-23-12-8-20(9-13-23)25(29)28-22-10-6-19(7-11-22)24-16-27-14-15-32-24/h2-13,24,27H,14-17H2,1H3,(H,28,29)
PubChem CID	67240705
ChEMBL	CHEMBL3919815
IUPHAR	N/A
BindingDB	250301
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	0.9 nM	, None	BindingDB,ChEMBL

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