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Name | Extracellular calcium-sensing receptor |
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Species | Homo sapiens (Human) |
Gene | CASR |
Synonym | hCasR {ECO:0000303|PubMed:27386547} GPRC2A extracellular calcium-sensing receptor Parathyroid cell calcium-sensing receptor 1 {ECO:0000303|PubMed:8698326} PCaR1 {ECO:0000303|PubMed:8698326} [ Show all ] |
Disease | Osteoporosis Cerebrovascular ischaemia Cardiovascular disease; Kidney disease Secondary hyperparathyroidism Myelodysplastic syndrome [ Show all ] |
Length | 1078 |
Amino acid sequence | MAFYSCCWVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSSSLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQPRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTRHEPLLPLQCGETDLDLTVQETGLQGPVGGDQRPEVEDPEELSPALVVSSSQSFVISGGGSTVTENVVNS |
UniProt | P41180 |
Protein Data Bank | 5k5t, 5k5s, 5fbk, 5fbh |
GPCR-HGmod model | N/A |
3D structure model | This structure is from PDB ID 5k5t. |
BioLiP | BL0353424,BL0353430, BL0353434, BL0353425,BL0353426,BL0353427,, BL0349612,BL0349615, BL0349611,BL0349614, BL0349610,BL0349613, BL0349606,BL0349609, BL0349605,BL0349608, BL0349604,BL0349607 |
Therapeutic Target Database | T92076 |
ChEMBL | CHEMBL1878 |
IUPHAR | 54 |
DrugBank | BE0000509 |
Name | CHEMBL3964061 |
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Molecular formula | C11H15N3O7S |
IUPAC name | (2S)-2-amino-3-[(2-methoxy-5-sulfophenyl)carbamoylamino]propanoic acid |
Molecular weight | 333.315 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 5 |
XlogP | -3.9 |
Synonyms | BDBM205520 SCHEMBL14471596 US9253997, 82 |
Inchi Key | CCUXLNHYXXNUFQ-ZETCQYMHSA-N |
Inchi ID | InChI=1S/C11H15N3O7S/c1-21-9-3-2-6(22(18,19)20)4-8(9)14-11(17)13-5-7(12)10(15)16/h2-4,7H,5,12H2,1H3,(H,15,16)(H2,13,14,17)(H,18,19,20)/t7-/m0/s1 |
PubChem CID | 71542724 |
ChEMBL | CHEMBL3964061 |
IUPHAR | N/A |
BindingDB | 205520 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
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EC50 | 1000.0 nM | , None | BindingDB,ChEMBL |
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