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GPCR

NameC-C chemokine receptor type 10
SpeciesHomo sapiens (Human)
GeneCCR10
SynonymCCR-10
CCR10
CC-CKR-10
G-protein coupled receptor 2
GPR-2
[ Show all ]
DiseaseInflammatory disease
Length362
Amino acid sequenceMGTEATEQVSWGHYSGDEEDAYSAEPLPELCYKADVQAFSRAFQPSVSLTVAALGLAGNGLVLATHLAARRAARSPTSAHLLQLALADLLLALTLPFAAAGALQGWSLGSATCRTISGLYSASFHAGFLFLACISADRYVAIARALPAGPRPSTPGRAHLVSVIVWLLSLLLALPALLFSQDGQREGQRRCRLIFPEGLTQTVKGASAVAQVALGFALPLGVMVACYALLGRTLLAARGPERRRALRVVVALVAAFVVLQLPYSLALLLDTADLLAARERSCPASKRKDVALLVTSGLALARCGLNPVLYAFLGLRFRQDLRRLLRGGSCPSGPQPRRGCPRRPRLSSCSAPTETHSLSWDN
UniProtP46092
Protein Data BankN/A
GPCR-HGmod modelP46092
3D structure modelThis predicted structure model is from GPCR-EXP P46092.
BioLiPN/A
Therapeutic Target DatabaseT71054
ChEMBLCHEMBL2321628
IUPHAR67
DrugBankN/A

Ligand

NameCHEMBL3948828
Molecular formulaC19H25Cl2N5O3S
IUPAC name4-amino-3,5-dichloro-N-[1-(4-methylpiperidin-1-yl)-1-oxo-4-pyrazol-1-ylbutan-2-yl]benzenesulfonamide
Molecular weight474.401
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP2.6
SynonymsSCHEMBL1312281
BDBM50199012
Inchi KeyCFQHZPAYYUFZES-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H25Cl2N5O3S/c1-13-3-8-25(9-4-13)19(27)17(5-10-26-7-2-6-23-26)24-30(28,29)14-11-15(20)18(22)16(21)12-14/h2,6-7,11-13,17,24H,3-5,8-10,22H2,1H3
PubChem CID58509238
ChEMBLCHEMBL3948828
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC501258.93 nMPMID27692854ChEMBL
IC501584.89 nMPMID27692854ChEMBL

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