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GPCR

NameAtypical chemokine receptor 3
SpeciesHomo sapiens (Human)
GeneACKR3
SynonymC-X-C chemokine receptor type 7
Cxcr7
CXCR-7
CXC-R7
chemokine (C-X-C motif) receptor 7
[ Show all ]
DiseaseAsthma
Cancer
Length362
Amino acid sequenceMDLHLFDYSEPGNFSDISWPCNSSDCIVVDTVMCPNMPNKSVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDASRVSETEYSALEQSTK
UniProtP25106
Protein Data BankN/A
GPCR-HGmod modelP25106
3D structure modelThis predicted structure model is from GPCR-EXP P25106.
BioLiPN/A
Therapeutic Target DatabaseT10491
ChEMBLCHEMBL2010631
IUPHAR80
DrugBankN/A

Ligand

NameCHEMBL3923474
Molecular formulaC30H41N5O2
IUPAC nameN-[3-[1-[4-(cyclohexylcarbamoyl)piperidin-1-yl]ethyl]phenyl]-5-pyrrolidin-1-ylpyridine-2-carboxamide
Molecular weight503.691
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP4.4
SynonymsBDBM243666
US9428456, 1.188
Inchi KeyCRVQMWXEIODKSL-UHFFFAOYSA-N
Inchi IDInChI=1S/C30H41N5O2/c1-22(34-18-14-23(15-19-34)29(36)32-25-9-3-2-4-10-25)24-8-7-11-26(20-24)33-30(37)28-13-12-27(21-31-28)35-16-5-6-17-35/h7-8,11-13,20-23,25H,2-6,9-10,14-19H2,1H3,(H,32,36)(H,33,37)
PubChem CID129626061
ChEMBLCHEMBL3923474
IUPHARN/A
BindingDB243666
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC50215.0 nM, NoneBindingDB,ChEMBL

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