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GPCR

NameTrace amine-associated receptor 1
SpeciesRattus norvegicus (Rat)
GeneTaar1
SynonymTRAR1
TaR-1
Trace amine receptor 1
TAR1
TA1 receptor
DiseaseN/A for non-human GPCRs
Length332
Amino acid sequenceMHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
UniProtQ923Y9
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3833
IUPHAR364
DrugBankN/A

Ligand

NameSCHEMBL1990370
Molecular formulaC19H19N5O
IUPAC name6-pyrazol-1-yl-N-(4-pyrrolidin-3-ylphenyl)pyridine-3-carboxamide
Molecular weight333.395
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP1.7
Synonyms1312567-10-4
3-Pyridinecarboxamide, 6-(1H-pyrazol-1-yl)-N-[4-(3-pyrrolidinyl)phenyl]-
BDBM250163
CHEMBL3900637
US9452980, 73
Inchi KeyCTMWZMVXWWFSTF-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H19N5O/c25-19(16-4-7-18(21-13-16)24-11-1-9-22-24)23-17-5-2-14(3-6-17)15-8-10-20-12-15/h1-7,9,11,13,15,20H,8,10,12H2,(H,23,25)
PubChem CID53250929
ChEMBLCHEMBL3900637
IUPHARN/A
BindingDB250163
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki25.7 nM, NoneBindingDB,ChEMBL

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