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GPCR

NameFree fatty acid receptor 4
SpeciesHomo sapiens (Human)
GeneFFAR4
SynonymO3FAR1
G-protein coupled receptor 120
GPR120
G-protein-coupled receptor GT01
G-protein coupled receptor PGR4
[ Show all ]
DiseaseN/A
Length377
Amino acid sequenceMSPECARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQTSEHLLDARAVVTHSEITKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNMTLCRNEWKKIFCCFWFPEKGAILTDTSVKRNDLSIISG
UniProtQ5NUL3
Protein Data BankN/A
GPCR-HGmod modelQ5NUL3
3D structure modelThis predicted structure model is from GPCR-EXP Q5NUL3.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5339
IUPHAR127
DrugBankBE0003399

Ligand

NameCHEMBL3986483
Molecular formulaC18H21ClF3NO4
IUPAC name2-[9-[2-chloro-5-(trifluoromethoxy)phenyl]-1-oxa-9-azaspiro[5.5]undecan-3-yl]acetic acid
Molecular weight407.814
Hydrogen bond acceptor8
Hydrogen bond donor1
XlogP4.3
Synonyms2-(9-(2-chloro-5-(trifluoromethoxy)phenyl)-1-oxa-9-azaspiro[5.5]undecan-3-yl)acetic acid
BDBM50208151
DIZADOFRCFKNSD-UHFFFAOYSA-N
SCHEMBL16466452
Inchi KeyDIZADOFRCFKNSD-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H21ClF3NO4/c19-14-2-1-13(27-18(20,21)22)10-15(14)23-7-5-17(6-8-23)4-3-12(11-26-17)9-16(24)25/h1-2,10,12H,3-9,11H2,(H,24,25)
PubChem CID73776997
ChEMBLCHEMBL3986483
IUPHARN/A
BindingDB50208151
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC501294.0 nMN/ABindingDB
EC502100.0 nMPMID28105274BindingDB,ChEMBL
EC505700.0 nMPMID28105274BindingDB,ChEMBL

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