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GLASS

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GPCR

Name	Metabotropic glutamate receptor 3
Species	Rattus norvegicus (Rat)
Gene	Grm3
Synonym	mGluR3 mGlu3 receptor GPRC1C glutamate receptor
Disease	N/A for non-human GPCRs
Length	879
Amino acid sequence	MKMLTRLQILMLALFSKGFLLSLGDHNFMRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAANRVNASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRQVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKEYLLKINFTAPFNPNKGADSIVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPEDYIKWEDAWAIGPVTIACLGFLCTCIVITVFIKHNNTPLVKASGRELCYILLFGVSLSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLPEKRETVILKCNVKDSSMLISLTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQKNVVTHRLHLNRFSVSGTATTYSQSSASTYVPTVCNGREVLDSTTSSL
UniProt	P31422
Protein Data Bank	2e4u, 2e4v, 2e4w, 2e4x, 2e4y
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 2e4u.
BioLiP	BL0086116,BL0086117, BL0086120,BL0086121, BL0086118,BL0086119, BL0086114,BL0086115, BL0086112,BL0086113
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3067
IUPHAR	291
DrugBank	N/A

Ligand

Name	CHEMBL3287719
Molecular formula	C23H28O7
IUPAC name	3-[4-(4-butanoyl-3-hydroxy-2-methylphenoxy)butoxy]-4-methoxybenzoic acid
Molecular weight	416.47
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	4.8
Synonyms	BDBM50017265 SCHEMBL17176263
Inchi Key	CYOPXIQIQFTMBB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H28O7/c1-4-7-18(24)17-9-11-19(15(2)22(17)25)29-12-5-6-13-30-21-14-16(23(26)27)8-10-20(21)28-3/h8-11,14,25H,4-7,12-13H2,1-3H3,(H,26,27)
PubChem CID	90643884
ChEMBL	CHEMBL3287719
IUPHAR	N/A
BindingDB	50017265
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
%max	64.2 %	PMID24735492	ChEMBL
EC50	496.0 nM	PMID24735492	BindingDB,ChEMBL

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