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GPCR

NameFree fatty acid receptor 4
SpeciesHomo sapiens (Human)
GeneFFAR4
SynonymO3FAR1
G-protein coupled receptor 120
GPR120
G-protein-coupled receptor GT01
G-protein coupled receptor PGR4
[ Show all ]
DiseaseN/A
Length377
Amino acid sequenceMSPECARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQTSEHLLDARAVVTHSEITKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNMTLCRNEWKKIFCCFWFPEKGAILTDTSVKRNDLSIISG
UniProtQ5NUL3
Protein Data BankN/A
GPCR-HGmod modelQ5NUL3
3D structure modelThis predicted structure model is from GPCR-EXP Q5NUL3.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5339
IUPHAR127
DrugBankBE0003399

Ligand

NameCHEMBL3967504
Molecular formulaC19H25ClF3NO2
IUPAC name2-[3-[2-chloro-5-(trifluoromethoxy)phenyl]-3-azaspiro[5.5]undecan-9-yl]ethanol
Molecular weight391.859
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP6.3
SynonymsSCHEMBL16482972
BDBM50208152
Inchi KeyGTNYJWYYNOSATA-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H25ClF3NO2/c20-16-2-1-15(26-19(21,22)23)13-17(16)24-10-8-18(9-11-24)6-3-14(4-7-18)5-12-25/h1-2,13-14,25H,3-12H2
PubChem CID117886649
ChEMBLCHEMBL3967504
IUPHARN/A
BindingDB50208152
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC50330.0 nMPMID28105274ChEMBL
EC50472.0 nMN/ABindingDB
EC504300.0 nMPMID28105274BindingDB,ChEMBL

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