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GPCR

NameMelanin-concentrating hormone receptor 1
SpeciesHomo sapiens (Human)
GeneMCHR1
SynonymSLC-1
Somatostatin receptor-like protein
MCHR-1
MCHR
MCH1R
[ Show all ]
DiseaseObesity
Obesity; Anxiety; Depression
Length422
Amino acid sequenceMSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProtQ99705
Protein Data BankN/A
GPCR-HGmod modelQ99705
3D structure modelThis predicted structure model is from GPCR-EXP Q99705.
BioLiPN/A
Therapeutic Target DatabaseT09572
ChEMBLCHEMBL344
IUPHAR280
DrugBankBE0003478

Ligand

NameCHEMBL181251
Molecular formulaC23H23BrF3N5O2
IUPAC name[4-bromo-2-(trifluoromethoxy)phenyl]-[4-[[4-(dimethylamino)quinazolin-2-yl]amino]piperidin-1-yl]methanone
Molecular weight538.369
Hydrogen bond acceptor9
Hydrogen bond donor1
XlogP5.9
SynonymsBDBM50170188
SCHEMBL13793628
(4-Bromo-2-trifluoromethoxy-phenyl)-[4-(4-dimethylamino-quinazolin-2-ylamino)-piperidin-1-yl]-methanone
Inchi KeyAHAIAGUVLZQAPM-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H23BrF3N5O2/c1-31(2)20-16-5-3-4-6-18(16)29-22(30-20)28-15-9-11-32(12-10-15)21(33)17-8-7-14(24)13-19(17)34-23(25,26)27/h3-8,13,15H,9-12H2,1-2H3,(H,28,29,30)
PubChem CID44390748
ChEMBLCHEMBL181251
IUPHARN/A
BindingDB50170188
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC501200.0 nMPMID16002290BindingDB,ChEMBL

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