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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 8
Species	Homo sapiens (Human)
Gene	TAS2R8
Synonym	T2R8 TAS2R8 Taste receptor family B member 5 taste receptor, type 2, member 8 TRB5
Disease	N/A
Length	309
Amino acid sequence	MFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProt	Q9NYW2
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYW2
3D structure model	This predicted structure model is from GPCR-EXP Q9NYW2.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3988599
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1279237
Molecular formula	C19H25N5O3
IUPAC name	5-(cyclohexylmethyl)-3-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]imidazolidine-2,4-dione
Molecular weight	371.441
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	3.0
Synonyms	CHEMBL3953908 BDBM211309 US9247759, 10-57
Inchi Key	HPNLTALDYBYGNU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H25N5O3/c1-12-16(13(2)27-22-12)11-23-10-15(9-20-23)24-18(25)17(21-19(24)26)8-14-6-4-3-5-7-14/h9-10,14,17H,3-8,11H2,1-2H3,(H,21,26)
PubChem CID	57944935
ChEMBL	CHEMBL3953908
IUPHAR	N/A
BindingDB	211309
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	960.0 nM	None	ChEMBL
IC50	960.0 nM	N/A	BindingDB

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