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GPCR

NameMelanocortin receptor 4
SpeciesHomo sapiens (Human)
GeneMC4R
SynonymMC4-R
MC4 receptor
DiseaseObesity; Sexual dysfunction
Obesity; Diabetes
Obesity
Metabolic disorders
Sexual dysfunction
[ Show all ]
Length332
Amino acid sequenceMVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
UniProtP32245
Protein Data BankN/A
GPCR-HGmod modelP32245
3D structure modelThis predicted structure model is from GPCR-EXP P32245.
BioLiPN/A
Therapeutic Target DatabaseT72458
ChEMBLCHEMBL259
IUPHAR285
DrugBankN/A

Ligand

NameMLS003124182
Molecular formulaC23H22N4O
IUPAC nameN-[6-[2-(dimethylamino)phenyl]-3-phenylimidazo[1,2-a]pyridin-8-yl]acetamide
Molecular weight370.456
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP4.3
SynonymsCHEMBL1999215
SMR001292852
Inchi KeyAHAQUYPPTMSFOL-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H22N4O/c1-16(28)25-20-13-18(19-11-7-8-12-21(19)26(2)3)15-27-22(14-24-23(20)27)17-9-5-4-6-10-17/h4-15H,1-3H3,(H,25,28)
PubChem CID49789721
ChEMBLCHEMBL1999215
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50<89177.0 nMPubChem BioAssay data setChEMBL

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